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KMID : 0370220200640050387
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Yakhak Hoeji
2020 Volume.64 No. 5 p.387 ~ p.393
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Role of Nitric Oxide in the TRPV1-mediated Melanogenesis
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Lee Yong-Soo
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Abstract
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We investigated the possible role of transient receptor potential vanilloid 1 (TRPV1) in melanogenesis in B16melanoma cells. Capsaicin (CAP), a TRPV1 agonist, increased production of melanin and nitric oxide (NO) in a dosedependentmanner, which was inhibited by capsazepine (CPZ), a TRPV1 antagonist. The CAP-induced melanin synthesiswas blocked by L-NAME and cPTIO, an inhibitor of NO synthase and a NO scavenger, respectively. CAP increasedintracellular Ca2+ concentration and BAPTA/AM, an intracellular Ca2+ chelator, inhibited the CAP-induced production ofNO and melanin. These results suggest that TRPV1 may stimulate melanogenesis through intracellular Ca2+-mediatedproduction of NO.
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KEYWORD
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TRPV1, melanogenesis, capsaicin, nitric oxide, B16 melanoma cell
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